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Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
Gene Name: | pumilio RNA-binding family member 2 |
Synonyms: | PUM2, KIAA0235, Pumilio homolog 2 (Drosophila), PUMH2, Pumilio (Drosphila) homolog 2, Pumilio-2, Pumilio homolog 2, PUML2 |
Target Sequences: | NM_015317 NP_056132.1 Q8TB72 |
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