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PTPN3 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | protein tyrosine phosphatase, non-receptor type 3 |
Family/Subfamily: | Protein Phosphatase , NT5 |
Synonyms: | PTPN3, PTP-H1, PTPH1 |
Target Sequences: | NM_002829 NP_002820.3 P26045 |
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