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Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Gene Name: | pleiotrophin |
Family/Subfamily: | Hormone , not assigned-Hormone |
Synonyms: | PTN, HARP, HBGF-8, HBNF, HB-GAM, HBBM, HBNF-1, Pleiotrophin, OSF-1, Osteoblast-specific factor 1, HBGF8, HBNF1, NEGF1 |
Target Sequences: | NM_002825 NP_002816.1 P21246 |
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