Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Goat Polyclonal (IgG) to Human PSEN2 / Presenilin 2
IHC - Paraffin, IHC - Frozen, ELISA
Human PSEN2 / Presenilin 2
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin
IHC - Frozen (1:1000)
Specificity and Use
PSEN2 / Presenilin 2 antibody was raised against synthetic peptide corresponding to amino acids 31-47 of Presenilin-2.
Recognizes human Presenilin-2, binding to neurons in both normal and Alzheimer's disease brain. Mutation of Presenilin-2 is associated with the early onset form of autosomal dominant Alzheimer's disease.
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP.