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Anti-PSEN2 / Presenilin 2 Antibody (aa31-47) LS-C11498

Note: This antibody replaces LS-C42808


Wt. Vol. Conc. Price
- 100 µl - $355
Inquire for larger quantities

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Goat Polyclonal (IgG) to Human PSEN2 / Presenilin 2
IHC - Paraffin, IHC - Frozen, ELISA


Human PSEN2 / Presenilin 2
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal


  • IHC - Paraffin (1:300)
  • IHC - Frozen (1:1000)
  • ELISA (1:20000)

Specificity and Use

PSEN2 / Presenilin 2 antibody was raised against synthetic peptide corresponding to amino acids 31-47 of Presenilin-2.
Recognizes human presenilin-2 (PSEN2), binding to neurons in both normal and Alzheimer's disease brain. Mutation of PSEN2 is associated with the early onset form of autosomal dominant Alzheimer's disease. PSEN2 is an essential component of the gamma-secretase complex along with APH-1 (APH-1A or APH-1B), PSEN1, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.
Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.


Serum, 0.09% sodium azide.
For research use only.

About PSEN2 / Presenilin 2

P49810 NM_000447 NP_000438.2

PSEN2 Antibody, AD3LP Antibody, AD4 Antibody, AD5 Antibody, AD3L Antibody, CMD1V Antibody, PS-2 Antibody, PSNL2 Antibody, PS2 Antibody, STM2 Antibody, Presenilin 2 Antibody, STM-2 Antibody, E5-1 Antibody, Presenilin-2 Antibody

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP.

Requested From: United States
Date Requested: 10/23/2016

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