Presenilin 2 antibody LS-C11498 is an unconjugated goat polyclonal antibody to human Presenilin 2 (PSEN2). Validated for ELISA and IHC.
Human PSEN2 / Presenilin 2
(tested or 100% immunogen sequence identity)
- IHC - Paraffin (1:300)
- IHC - Frozen (1:1000)
- ELISA (1:20000)
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Synthetic peptide corresponding to amino acids 31-47 of Presenilin-2.
Recognizes human presenilin-2 (PSEN2), binding to neurons in both normal and Alzheimer's disease brain. Mutation of PSEN2 is associated with the early onset form of autosomal dominant Alzheimer's disease. PSEN2 is an essential component of the gamma-secretase complex along with APH-1 (APH-1A or APH-1B), PSEN1, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes.
Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Serum, 0.09% Sodium Azide
For research use only.
About PSEN2 / Presenilin 2