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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PSEN1 / Presenilin 1 Antibody (phospho‑Ser357) LS‑C199498
Presenilin 1 antibody LS-C199498 is an unconjugated rabbit polyclonal antibody to Presenilin 1 (PSEN1) from human, mouse and rat. Validated for IHC, Peptide-ELISA and WB.
Catalog
Size
Price
LS-C199498-50
50 µl
Unavailable
LS-C199498-100
100 µl
Unavailable

Popular PSEN1 / Presenilin 1 Products

Antibody
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation, ELISA
Antibody
Species: Human, Mouse, Rat, Xenopus
Applications: Western blot, ELISA
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Anti-PSEN1 / Presenilin 1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6832 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bat, Dog, Guinea pig, Hamster, Pig
Applications: IHC, IHC - Paraffin, Western blot
Western blot analysis of extracts of 293 cells.
Species: Human, Mouse
Applications: IHC, Immunofluorescence, Western blot, Flow Cytometry

Product Description

Presenilin 1 antibody LS-C199498 is an unconjugated rabbit polyclonal antibody to Presenilin 1 (PSEN1) from human, mouse and rat. Validated for IHC, Peptide-ELISA and WB.
About PSEN1 / Presenilin 1
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. P49768 NM_000021 NP_000012.1

PSEN1 Antibody, AD3 Antibody, Alzheimer disease 3 Antibody, FAD Antibody, Protein S182 Antibody, PS1 Antibody, S182 Antibody, PS-1 Antibody, PSNL1 Antibody, Presenilin 1 Antibody, Presenilin-1 Antibody


Specifications

Target
Human PSEN1 / Presenilin 1
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:50 - 1:100)
  • Western blot (1:500 - 1:1000)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:5000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide derived from human PSEN1 around the phosphorylation site of Ser357.
Epitope
pSer357
Specificity
PSEN1 (Phospho-Ser357) Antibody detects endogenous levels of PSEN1 only when phosphorylated at serine357.
Presentation
PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Storage
Store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

IHC of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The sample on the right was incubated with synthetic peptide.
IHC of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The sample on the right was incubated with synthetic peptide.

Western blot

Western blot of extracts from RAW264.7 cells treated with UV 5', using PSEN1 (Phospho-Ser357) Antibody. The lane on the right was incubated with synthetic peptide.
Western blot of extracts from RAW264.7 cells treated with UV 5', using PSEN1 (Phospho-Ser357) Antibody. The lane on the right was incubated with synthetic peptide.

Immunohistochemistry

IHC of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The sample on the right was incubated with synthetic peptide.
IHC of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The sample on the right was incubated with synthetic peptide.

Western blot

Western blot of extracts from RAW264.7 cells treated with UV 5', using PSEN1 (Phospho-Ser357) Antibody. The lane on the right was incubated with synthetic peptide.
Western blot of extracts from RAW264.7 cells treated with UV 5', using PSEN1 (Phospho-Ser357) Antibody. The lane on the right was incubated with synthetic peptide.

Immunohistochemistry

IHC of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The sample on the right was incubated with synthetic peptide.
IHC of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The sample on the right was incubated with synthetic peptide.

Western blot

Western blot of extracts from RAW264.7 cells treated with UV 5', using PSEN1 (Phospho-Ser357) Antibody. The lane on the right was incubated with synthetic peptide.
Western blot of extracts from RAW264.7 cells treated with UV 5', using PSEN1 (Phospho-Ser357) Antibody. The lane on the right was incubated with synthetic peptide.

Immunohistochemistry

IHC of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The sample on the right was incubated with synthetic peptide.
IHC of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The sample on the right was incubated with synthetic peptide.

Western blot

Western blot of extracts from RAW264.7 cells treated with UV 5', using PSEN1 (Phospho-Ser357) Antibody. The lane on the right was incubated with synthetic peptide.
Western blot of extracts from RAW264.7 cells treated with UV 5', using PSEN1 (Phospho-Ser357) Antibody. The lane on the right was incubated with synthetic peptide.


Requested From: 
Date Requested: 6/22/2018

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