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Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Gene Name: | pleckstrin and Sec7 domain containing 4 |
Synonyms: | PSD4, EFA6B, Exchange factor for ARF6 B, SEC7 homolog, TIC |
Target Sequences: | NM_012455 NP_036587.2 Q8NDX1 |
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