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PROZ / Protein Z is a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.
Gene Name: | protein Z, vitamin K-dependent plasma glycoprotein |
Synonyms: | PROZ, Vitamin K-dependent protein Z, Protein Z, PZ |
Target Sequences: | NM_003891 NP_003882.1 P22891 |
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