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PROS1 / Protein S is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3.
Gene Name: | protein S (alpha) |
Synonyms: | PROS1, Protein S (alpha), Protein S alpha, Protein Sa, PS22, PS21, Vitamin K-dependent protein S, THPH5, THPH6, PROS, PS24, Protein S, PS23, PS25 |
Target Sequences: | NM_000313 NP_000304.2 P07225 |
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