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PROC / Protein C is a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
Gene Name: | protein C (inactivator of coagulation factors Va and VIIIa) |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | PROC, Anticoagulant protein C, Blood coagulation factor XIV, Autoprothrombin IIA, Protein C, PROC1, Vitamin K-dependent protein C, THPH3, THPH4 |
Target Sequences: | NM_000312 NP_000303.1 P04070 |
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