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PPP1R1B / DARPP-32 is a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | protein phosphatase 1, regulatory (inhibitor) subunit 1B |
Family/Subfamily: | Protein Phosphatase Regulatory Subunit |
Synonyms: | PPP1R1B, DARPP-32, DARPP32 |
Target Sequences: | NM_032192 NP_115568.2 Q9UD71 |
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