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Anti-POLI Antibody (aa690-706) LS-C3374

Ordering

Wt. Vol. Conc. Price
100 µg - - $265
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Rabbit Polyclonal to Human POLI
Human
ELISA
Unconjugated

Details

Human POLI
Rabbit
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
Polyclonal
Protein G purified

Applications

ELISA (1:1000)
IHC - Paraffin

Specificity and Use

POLI antibody was raised against synthetic peptide from human POLI. Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Elephant, Opossum (94%); Bat, Dog, Bovine, Horse, Pig (88%); Mouse, Rat, Hamster, Panda (81%).
aa690-706
KLH conjugated synthetic peptide comprising amino acids 690 - 706 [ELPEAVQKELLAEWKRC] of the human DNA polymerase iota (POLI) protein.

Packaging

PBS, 0.09% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About POLI

Q9UNA4 NM_007195 NP_009126.2

POLI Antibody, DNA polymerase iota Antibody, Eta2 Antibody, Polymerase (DNA directed) iota Antibody, RAD30 homolog B Antibody, RAD3OB Antibody, RAD30B Antibody

Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes.

Requested From: United States
Date Requested: 9/27/2016

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