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Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca2+/Mg2+-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.
Gene Name: | Plexin B3 |
Synonyms: | PLXNB3, Plexin 6, Plexin B3, KIAA1206, PLEXB3, Plexin-B3, PLEXR, PLXN6 |
Target Sequences: | NM_005393 NP_005384.2 Q9ULL4 |
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