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Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Gene Name: | plexin A2 |
Synonyms: | PLXNA2, OCT, Plexin 2, KIAA0463, Semaphorin receptor OCT, PLXN2, Transmembrane protein OCT, Plexin A2, Plexin-A2 |
Target Sequences: | D86949 BAA13189.1 P70207 |
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