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Anti-PLP1 / Myelin PLP Antibody (C-Terminus) IHC-plus™ LS-B7759

Note: This antibody replaces LS-C25718

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $450
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular PLP1 / Myelin PLP Antibodies

Anti-PLP1 / Myelin PLP Antibody (C-Terminus, clone plpc1) IHC-plus™ LS-B2867
Mouse Monoclonal [clone plpc1] (IgG2a) to Bovine PLP1 / Myelin PLP
Bovine, Human, Mammal
IHC - Paraffin, IHC - Frozen, Western blot
Unconjugated
Immunohistochemistry Image
Anti-PLP1 / Myelin PLP Antibody (aa36-85) IHC-plus™ LS-B6535
Rabbit Polyclonal to Human PLP1 / Myelin PLP
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-PLP1 / Myelin PLP Antibody (clone NYRPLP) LS-C204675
Mouse Monoclonal [clone NYRPLP] (IgG1) to Human PLP1 / Myelin PLP
Human
IHC, Western blot, Immunoprecipitation, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG2a) to Human PLP1 / Myelin PLP
Human, Mammal
IHC - Paraffin, IHC - Frozen, ICC, Western blot
Unconjugated

Details

Human PLP1 / Myelin PLP
Mouse
Human, Mammal (tested or 100% immunogen sequence identity)
IgG2a Monoclonal
Unconjugated
Purified
Unmodified

Applications

  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen
  • ICC
  • Western blot

Specificity and Use

PLP1 / Myelin PLP antibody was raised against myelin proteolipid protein, synthetic peptide CGRGTKF corresponding to the C-terminal peptide.
C-Terminus
Reacts with myelin proteolipid protein in many mammalian species. Shows cross-reactivity to DM20.
Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry. Western Blot: Can aggregate causing HMW bands to sometimes appear in certain preparations. Immunocytochemistry: 4% PFA fixed cells for 5-10 minutes at RT. Use 0.1% triton in block only to allow antibody access to C-terminal epitope. Immunohistochemistry (Frozen): Fresh frozen sections or 4% PFA fixed, frozen tissues. Epitope is internal, use 0.1-0.2% triton X-100 in the blocking step for permeabilization. Immunohistochemistry (Paraffin): Works best with lightly fixed tissues, or Bouin's fixed material, although there are reports of traditional formalin fixation also working with antigen recovery. Positive control: Brain.

Packaging

PBS buffer, pH 7.2, 0.09% sodium azide
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About PLP1 / Myelin PLP

NM_000533 NP_000524.3

PLP1 Antibody, HLD1 Antibody, PMD Antibody, Myelin proteolipid protein Antibody, Proteolipid protein 1 Antibody, SPG2 Antibody, Lipophilin Antibody, MMPL Antibody, PLP Antibody, PLP/DM20 Antibody

PLP1 / Myelin PLP is a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant.

Immunohistochemistry

Immunohistochemistry
Anti-PLP1 antibody IHC of human brain cerebellum, neuropil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7759 dilution 10 ug/ml.
 

Requested From: United States
Date Requested: 12/3/2016

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