Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone PVM-1] (IgG1) to Plasmodium vivax MSP-1
Western blot, ELISA
Plasmodium vivax MSP-1
Plasmodium vivax (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [PVM-1]
Specificity and Use
Recognizes the merozoite surface protein 1 (MSP1) of Plasmodium vivax, a protozoan parasite that causes malaria in humans. Malaria caused by P. vivax is seldom lethal but is the most common outside sub-Saharan Africa. The parasite is transmitted by Anopheles mosquitoes. Merozoites are the result of asexual reproduction of the parasite in the hepatocytes. They are released from hepatocytes and infected erythrocytes to infect other erythrocytes. MSP1 is the most abundant protein on the surface of merozoites and is involved in parasite invasion of the erythrocyte. It has long been considered a promising candidate for a vaccine against malaria. Some studies have shown that naturally acquired antibodies to a cleavage product of MSP1 can be linked to a reduced risk of clinical malaria.