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Pirin / PIR is a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
Gene Name: | pirin (iron-binding nuclear protein) |
Synonyms: | PIR, Probable quercetinase, Pirin |
Target Sequences: | NM_003662 NP_003653.1 O00625 |
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