The Immunohistochemistry Antibody Company
|Mouse (tested or 100% immunogen sequence identity)|
|PIF1 antibody was raised against synthetic peptide made to an internal portion of the human PIF1 protein (between residues 400-500)|
|Staining was observed in the nucleus of mouse brain tissue. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.|
|PBS, 30% glycerol containing 0.05% sodium azide|
|Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|For research use only.|
PIF1 Antibody, C15orf20 Antibody, DNA helicase homolog PIF1 Antibody, PIF Antibody, Petite integration frequency 1 Antibody, PIF1 DNA helicase Antibody, DNA helicase PIF1 AntibodyDNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase.