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Anti-PDX1 Antibody (aa198-213) IHC-plus™ LS-B3086

Note: This antibody replaces LS-C74226

Ordering

Wt. Vol. Conc. Price
50 µg - 0.5 mg/ml $395

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

PDX1 Antibody LS-B3086 Images

[click image for a larger image and more details]
Immunohistochemistry
Anti-PDX1 antibody IHC of human pancreas.

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Rabbit Polyclonal (IgG) to Human PDX1
Human, Monkey, Rabbit
IHC - Paraffin, ELISA
Unconjugated

Details

Human PDX1
Rabbit
Human, Monkey, Rabbit (tested or 100% immunogen sequence identity)
Bat (at least 90% immunogen sequence identity)
IgG Polyclonal
Immunoaffinity purified

Applications

IHC - Paraffin (5 µg/ml), ELISA

Specificity and Use

PDX1 antibody was raised against synthetic peptide, aa198-213 RMKWKKEEDKKRGGGT corresponding to human Pdx1 (KLH). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Rabbit (100%); Bat, Opossum (94%); Mouse, Rat, Hamster, Dog (88%); Turkey, Chicken, Xenopus (81%).
aa198-213
Recognizes human Pdx1. Species cross-reactivity: rodent.
Immunohistochemistry: LS-B3086 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B3086 was determined to be 5 ug/ml.

Packaging

PBS, pH 7.2, sodium azide, before the addition of glycerol to 40%
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About PDX1

P52945 NM_000209 NP_000200.1

PDX1 Antibody, Glucose-sensitive factor Antibody, Insulin upstream factor 1 Antibody, IPF1 Antibody, Insulin promoter factor 1 Antibody, IPF-1 Antibody, IUF-1 Antibody, STF-1 Antibody, GSF Antibody, IDX-1 Antibody, Islet/duodenum homeobox-1 Antibody, IUF1 Antibody, MODY4 Antibody, PDX-1 Antibody

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.

Immunohistochemistry

Immunohistochemistry
Anti-PDX1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3086 concentration 5 ug/ml.
 

Requested From: United States
Date Requested: 9/4/2015

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