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Anti-PDE6A / PDE6 Alpha Antibody (N-Terminus) IHC-plus™ LS-A730

Note: This antibody replaces LS-C90180, LS-C42461

Ordering

Wt. Vol. Conc. Price
50 µg - 0.23 mg/ml Unavailable
Same day shipping In Stock - Same day shipping

Most Popular PDE6A / PDE6 Alpha Antibodies

Anti-PDE6A / PDE6 Alpha Antibody (N-Terminus) IHC-plus™ LS-A730
Rabbit Polyclonal to Human PDE6A / PDE6 Alpha
Human, Monkey, Mouse, Rat, Hamster
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-PDE6A / PDE6 Alpha Antibody (aa308-336) LS-C158560
Rabbit Polyclonal to Human PDE6A / PDE6 Alpha
Human
Western blot
Unconjugated
Western blot Image
Anti-PDE6A / PDE6 Alpha Antibody (aa99-148) LS-C201668
Rabbit Polyclonal to Human PDE6A / PDE6 Alpha
Human, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Zebrafish
Western blot
Unconjugated
Western blot Image

100% Guaranteed 100% Guaranteed In Stock In Stock
Rabbit Polyclonal to Human PDE6A / PDE6 Alpha
Human, Monkey, Mouse, Rat, Hamster
IHC - Paraffin
Unconjugated

Details

Human PDE6A / PDE6 Alpha
Rabbit
Human, Monkey, Mouse, Rat, Hamster (tested or 100% immunogen sequence identity)
Dog, Rabbit (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

IHC - Paraffin (10 - 15 µg/ml)

Specificity and Use

PDE6A / PDE6 Alpha antibody was raised against synthetic 18 amino acid peptide from N-terminus of human PDE6A / PDE6 Alpha. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster (100%); Dog, Panda, Rabbit (94%); Bovine, Bat, Elephant (89%); Horse, Opossum (83%).
LS-E29248 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A730. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
N-Terminus
Human PDE6A / PDE6 Alpha. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Immunohistochemistry: LS-A730 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-A730 was determined to be 10 ug/ml.

Packaging

PBS, less than 0.1% sodium azide.
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles.
For research use only.

About PDE6A / PDE6 Alpha

P16499 NM_000440 NP_000431.2

PDE6A Antibody, Alpha-PDE Antibody, CGMP phosphodiesterase alpha Antibody, CGPR-A Antibody, PDE6alpha Antibody, PDE V-B1 Antibody, PDEA Antibody, Phosphodiesterase 6a Antibody, RP43 Antibody, GMP-PDE alpha Antibody

PDE6A is the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis.

Immunohistochemistry

Immunohistochemistry
Anti-PDE6A / PDE6 Alpha antibody LS-A730 IHC of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
 

Requested From: 
Date Requested: 3/26/2017

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