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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PDE4B Antibody (N‑Terminus) LS‑C9586
PDE4B antibody LS-C9586 is an unconjugated rabbit polyclonal antibody to PDE4B from human and rat. Validated for IP and WB.
Antibody
Catalog
Size
Price
LS-C9586-100
100 µg
$605

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Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Product Description

PDE4B antibody LS-C9586 is an unconjugated rabbit polyclonal antibody to PDE4B from human and rat. Validated for IP and WB.
About PDE4B
PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Q07343 NM_002600 NP_002591.2

PDE4B Antibody, Pde-ivb Antibody, PDE32 Antibody, PDE4B5 Antibody, PDEIVB Antibody, Phosphodiesterase 4b Antibody, DPDE4 Antibody, PDE4B3 Antibody


Specifications

Target
Human PDE4B
Host
Rabbit
Reactivity
Human, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1 - 3 µg/ml)
  • Immunoprecipitation (7 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
PDE4B antibody was raised against synthetic peptide derived from the N-terminal region of human and rat PDE4B protein.
Epitope
N-Terminus
Specificity
Reacts with the human and rat PDE4B protein. On Western blots, it identifies a single band at ~83kD. Bands of unknown origin may be observed at ~160 and ~260kD. Reactivities have been confirmed with NG96 human neuroblastoma lysate and rat brain homogenate.
Usage
Suitable for use in Immunoprecipitation and Western Blot. Recommended Dilution;. Immunoprecipitation: 7 ug/ml. Western Blot: 1-3 ug/ml.
Presentation
PBS, pH 7.4, 0.1% Sodium Azide
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/17/2018

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