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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PCSK9 Antibody (aa490‑502) LS‑C9764
PCSK9 antibody LS-C9764 is an unconjugated rabbit polyclonal antibody to human PCSK9. Validated for ICC, IF and WB.
Antibody
Catalog
Size
Price
LS-C9764-100
100 µg (0.4 mg/ml)
$545

Popular PCSK9 Products

Western blot of PCSK9 antibody LS-C146648.
Species: Human, Mouse, Rat
Applications: ICC, Western blot
Anti-PCSK9 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6939 concentration 5 ug/ml.
Species: Mouse, Human, Monkey, Rat
Applications: IHC, IHC - Paraffin, ICC, Western blot
HEK293 lysate (10ug protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with (1ug/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed (1mg/ml) in Lane B. Primary
Species: Human, Monkey, Mouse, Rat, Hamster
Applications: Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Antibody
Species: Human
Applications: IHC, Western blot, Flow Cytometry, ELISA
Antibody staining (0.2 ug/ml) of McA cell lysates: untransfected (1), transfected with wild type human pcsk9 (2), transfected with S127R human pcsk9 (3).
Species: Human
Applications: Western blot, Peptide Enzyme-Linked Immunosorbent Assay

Product Description

PCSK9 antibody LS-C9764 is an unconjugated rabbit polyclonal antibody to human PCSK9. Validated for ICC, IF and WB.

Specifications

Target
Human PCSK9
Synonyms
PCSK9, FH3, HCHOLA3, LDLCQ1, NARC-1, Proprotein convertase 9, NARC1, PC9
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • ICC
  • Immunofluorescence (1:25)
  • Western blot (1:100)
Immunogen
PCSK9 antibody was raised against synthetic peptide corresponding to aa490-502 [SRSGKRRGERMEA] of human PCSK9. Species sequence Homology. Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon (100%); Gorilla, Macaque, Monkey, Titi monkey, Woolly monkey, Colobus monkey, Tamarin (92%); Marmoset, Spider monkey, Elephant, Opossum (85%).
Epitope
aa490-502
Specificity
Recognizes human PCSK9. Detects mainly the mature form of the protein ranging from 62-66kD in tissues and cells such as liver, kidney and colon cancer cells. Species cross-reactivity: Mouse and rat. Species sequence Homology: Mouse: ~69% (9/13aa [SRSGrRRGdwiEA]); Rat: ~77% (10/13aa [SRSGrRRGdRiEA]).
Usage
Suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence. Western Blot: 1:100 (3 ug/ml). Immunofluorescence (IC): 1:25 (16 ug/ml).
Presentation
TBS, pH 7.4, 0.1% BSA, 0.02% sodium azide.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About PCSK9
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. Q8NBP7 NM_174936 NP_777596.2


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Requested From: United States
Date Requested: 10/19/2018

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