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Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
Gene Name: | alkB, alkylation repair homolog 3 (E. coli) |
Synonyms: | ALKBH3, ABH3, DEPC1, DEPC-1, Prostate cancer antigen 1, PCA1, Prostate cancer antigen-1 |
Target Sequences: | Q96Q83 Q96Q83 |
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