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Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.
Gene Name: | Proteasomal ATPase-associated factor 1 |
Synonyms: | PAAF1, PAAF, Protein G-16, WD repeat domain 71, Rpn14, WDR71 |
Target Sequences: | NM_025155 NP_079431.1 Q9BRP4 |
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