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P4HA3 is a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants.
Gene Name: | Prolyl 4-hydroxylase, alpha polypeptide III |
Synonyms: | P4HA3, 4-PH alpha-3, C-P4H alpha III, C-P4Halpha(III), p4HA3 |
Target Sequences: | Q7Z4N8 Q7Z4N8 |
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