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Anti-P2RX7 / P2X7 Antibody (clone Hano43, FITC) LS-C188552

Ordering

Wt. Vol. Conc. Price
100 µg - 0.1 mg/ml $275
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular P2RX7 / P2X7 Antibodies

Anti-P2RX7 / P2X7 Antibody (Internal) IHC-plus™ LS-A9585
Rabbit Polyclonal to Human P2RX7 / P2X7
Human, Monkey
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-P2RX7 / P2X7 Antibody (aa13-26) IHC-plus™ LS-B4401
Goat Polyclonal to Human P2RX7 / P2X7
Human, Hamster, Pig
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-P2RX7 / P2X7 Antibody (aa47-334, FITC) LS-C424040
Rabbit Polyclonal (IgG) to Human P2RX7 / P2X7
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
FITC Conjugated

100% Guaranteed 100% Guaranteed
Rat Monoclonal [clone Hano43] (IgG2b) to Mouse P2RX7 / P2X7
Mouse
Immunofluorescence, Flow Cytometry (applications tested for the base form of this product only)
FITC Conjugated

Details

Mouse P2RX7 / P2X7
Rat
Mouse (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [Hano43]
Fluorescein. Also available Unconjugated.
Protein G purified
Unmodified

Applications

  • Immunofluorescence
  • Flow Cytometry
  • (applications tested for the base form of this product only)

Specificity and Use

P2RX7 / P2X7 antibody was raised against a P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Recognizes the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

PBS, 0.09% sodium azide, 1% BSA
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. Protect from light.
For research use only.

About P2RX7 / P2X7

Q99572 NM_002562 NP_002553.3

P2RX7 Antibody, ATP receptor Antibody, p2X purinoceptor 7 Antibody, p2X receptor 7 Antibody, p2X7 purinoceptor Antibody, p2Z receptor Antibody, Purinergic receptor Antibody, p2RX7 Antibody, p2X7 Antibody, p2X7 receptor Antibody

P2RX7 / P2X7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.

Requested From: United States
Date Requested: 12/10/2016

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