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OSBPL2 is a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
Gene Name: | oxysterol binding protein-like 2 |
Synonyms: | OSBPL2, OSBP-related protein 2, KIAA0772, ORP-2, ORP2 |
Target Sequences: | NM_014835 NP_055650.1 Q9H1P3 |
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