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OGFR is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported.
Gene Name: | opioid growth factor receptor |
Synonyms: | OGFR, 7-60, 7-60 protein, Opioid growth factor receptor, Zeta opioid receptor, Protein 7-60, Zeta-type opioid receptor |
Target Sequences: | NM_007346 NP_031372.2 Q9NZT2 |
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