Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Synthetic peptide derived from the N-terminal region of the human neuropilin-1 (Npn-1, NRP-1) protein.
Recognizes soluble and membrane-bound forms of human neuropilin-1. On Western blots, it identifies two bands, one at ~130-135kD representing the membrane-bound form and another at ~90kD for the soluble form. Reacts with human PC-3 prostate adenocarcinoma cell lysates. Species sequence homology: chicken and frog Npn-1. (Mouse and rat cross-reactivity is also possible).
Suitable for use in ELISA and Western Blot. ELISA: 0.1-1 ug/ml. Western Blot: 1-3 ug/ml.
PBS, pH 7.4, 0.09% Sodium Azide
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis.