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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NR1H4 / FXR Antibody (C‑Terminus, DY650) LS‑C142217
FXR antibody LS-C142217 is a DY650-conjugated rabbit polyclonal antibody to human FXR (NR1H4). Validated for WB.
Catalog
Size
Price
LS-C142217-100
100 µl
Unavailable

Popular NR1H4 / FXR Products

Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: Western blot
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Species: Human, Rat
Applications: IHC, Western blot, Immunoprecipitation, ELISA
Anti-NR1H4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B987 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig
Applications: IHC, IHC - Paraffin, Western blot
NR1H4 antibody LS-C107782 Western blot of THP-1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Guinea pig
Applications: Western blot
Antibody
Species: Human, Monkey, Horse, Pig, Rabbit
Applications: Western blot

Product Description

FXR antibody LS-C142217 is a DY650-conjugated rabbit polyclonal antibody to human FXR (NR1H4). Validated for WB.
About NR1H4 / FXR
Farnesoid X receptor (FXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect bile-acid metabolism in the liver and intestine. FXR binds to target DNA as a heterodimer (with retinoid X receptors) and is activated by bile acids. Binding of bile acids to the RXR/FXR heterodimer in liver represses CYP7A1 expression and bile-acid production, leading to a failure to solubilize and absorb cholesterol. Q96RI1 NM_005123 NP_005114.1

NR1H4 Antibody, BAR Antibody, Farnesyl x receptor Antibody, FXR Antibody, HRR1 Antibody, Farnesoid x activated receptor Antibody, Farnesoid X receptor Antibody, Farnesol receptor HRR-1 Antibody, HRR-1 Antibody, RXR-interacting protein 14 Antibody, RIP14 Antibody, Bile acid receptor Antibody, Farnesoid X nuclear receptor Antibody, Farnesoid X-activated receptor Antibody


Specifications

Target
Human NR1H4 / FXR
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
DyLight 650. Also available Unconjugated or conjugated with Biotin, DY488, DY550.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (4 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
NR1H4 / FXR antibody was raised against a synthetic peptide made to the C-terminus of the human FXR protein
Epitope
C-Terminus
Specificity
FXR.
Usage
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
50 mM sodium borate
Storage
Store at 4°C. Do not freeze.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/21/2018

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