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Anti-NR1H4 / FXR Antibody (C-Terminus, DY650) LS-C142217

Catalog Size Price
LS-C142217-100 100 µl Unavailable

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100% Guaranteed
Rabbit Polyclonal to Human NR1H4 / FXR
Western blot (applications tested for the base form of this product only)
DY650 Conjugated


Human NR1H4 / FXR
Human (tested or 100% immunogen sequence identity)
DyLight 650. Also available Unconjugated or conjugated with Biotin, DY488, DY550.
Immunoaffinity purified


  • Western blot (4 µg/ml)
  • (applications tested for the base form of this product only)

Specificity and Use

NR1H4 / FXR antibody was raised against a synthetic peptide made to the C-terminus of the human FXR protein
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.


50 mM sodium borate
Store at 4°C. Do not freeze.
For research use only.

About NR1H4 / FXR

Q96RI1 NM_005123 NP_005114.1

NR1H4 Antibody, BAR Antibody, Farnesyl x receptor Antibody, FXR Antibody, HRR1 Antibody, Farnesoid x activated receptor Antibody, Farnesoid X receptor Antibody, Farnesol receptor HRR-1 Antibody, HRR-1 Antibody, RXR-interacting protein 14 Antibody, RIP14 Antibody, Bile acid receptor Antibody, Farnesoid X nuclear receptor Antibody, Farnesoid X-activated receptor Antibody

Farnesoid X receptor (FXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect bile-acid metabolism in the liver and intestine. FXR binds to target DNA as a heterodimer (with retinoid X receptors) and is activated by bile acids. Binding of bile acids to the RXR/FXR heterodimer in liver represses CYP7A1 expression and bile-acid production, leading to a failure to solubilize and absorb cholesterol.

Western blot

Western blot
Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: 
Date Requested: 2/19/2018

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