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Anti-NR1H4 / FXR Antibody (aa194-243) IHC-plus™ LS-B987

Note: This antibody replaces LS-C29905

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $450
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular NR1H4 / FXR Antibodies

Anti-NR1H4 / FXR Antibody (aa2-126) LS-C6986
Mouse Monoclonal (IgG2a) to Human NR1H4 / FXR
Human, Rat
IHC, Western blot, Immunoprecipitation, ELISA
Unconjugated
Anti-NR1H4 / FXR Antibody (aa194-243) IHC-plus™ LS-B987
Rabbit Polyclonal to Human NR1H4 / FXR
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-NR1H4 / FXR Antibody (aa323-372) LS-C107782
Rabbit Polyclonal (IgG) to Human NR1H4 / FXR
Human, Monkey, Guinea pig
Western blot
Unconjugated
Western blot Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human NR1H4 / FXR
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig
IHC - Paraffin, Western blot (applications tested for the base form of this product only)
Unconjugated

Details

Human NR1H4 / FXR
Rabbit
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig (tested or 100% immunogen sequence identity)
Hamster, Rabbit (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated. Also available conjugated with FITC, Biotin, HRP.
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • Western blot (0.2 - 1 µg/ml)
  • (applications tested for the base form of this product only)

Specificity and Use

NR1H4 / FXR antibody was raised against synthetic peptide located between aa194-243 of human NR1H4 (Q96RI1-2, NP_005114). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Elephant, Dog, Bovine, Bat, Horse, Pig, Guinea pig (100%); Hamster, Rabbit (92%); Turkey, Chicken (85%); Platypus (84%); M. tuberculosis (83%).
LS-E11908 - Lyophilized - 100 µg - $145.00
aa194-243
Human NR1H4
Immunohistochemistry: LS-B987 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B987 was determined to be 5 ug/ml.

Packaging

Lyophilized from PBS with 2% sucrose
Reconstitute with 50µl of distilled water
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than one week): +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About NR1H4 / FXR

Q96RI1 NM_005123 NP_005114.1

NR1H4 Antibody, BAR Antibody, Farnesyl x receptor Antibody, FXR Antibody, HRR1 Antibody, Farnesoid x activated receptor Antibody, Farnesoid X receptor Antibody, Farnesol receptor HRR-1 Antibody, HRR-1 Antibody, RXR-interacting protein 14 Antibody, RIP14 Antibody, Bile acid receptor Antibody, Farnesoid X nuclear receptor Antibody, Farnesoid X-activated receptor Antibody

Farnesoid X receptor (FXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect bile-acid metabolism in the liver and intestine. FXR binds to target DNA as a heterodimer (with retinoid X receptors) and is activated by bile acids. Binding of bile acids to the RXR/FXR heterodimer in liver represses CYP7A1 expression and bile-acid production, leading to a failure to solubilize and absorb cholesterol.

Immunohistochemistry

Immunohistochemistry
Anti-NR1H4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B987 concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Western blot
NR1H4 antibody LS-B987 Western blot of Fetal lung lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

Western blot
Fetal Lung Lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
 

Requested From: United States
Date Requested: 12/10/2016

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