Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone ANK44] (IgG1) to Rat NK cells / NKR-P1
IHC - Frozen, Immunoprecipitation, Flow Cytometry
Rat NK cells / NKR-P1
Rat (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [ANK44]
Tissue culture supernatant
IHC - Frozen
Specificity and Use
The antigen recognized by ANK44 is highly expressed on rat NK cells after IL-2-activation. The antigen is not expressed by unstimulated NK cells. ANK44 also binds to rat ?d-TCR T cells. It does not bind to abeta-TCR T cells or to B cells. The ANK44 monoclonal antibody is rat strain-independent. The ANK44 monoclonal antibody was generated by immunizing mice with IL-2-activated cultured NK cells of Wag rats (Giezeman-Smits et al., 1998).
ANK44 is suitable for flow cytometry, immunohistochemical analysis of freshly frozen tissue sections and for immunoprecipitation of the antigen.