NISCH

nischarin

Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension By similarity. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons By similarity. Acts as a modulator of Rac-regulated signal transduction pathways By similarity. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity By similarity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation By similarity. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation By similarity. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells By similarity. Inhibits lamellipodia formation, when overexpressed By similarity. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

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Products

Antibodies (23)

Proteins (6)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (23)

Recombinant (4)

Sandwich (1)

Target

NISCH (30)

Reactivity

Human (16)

Mouse (11)

Rat (1)

Application

IHC (1)

IHC-P (1)

WB (21)

ELISA (4)

IP (2)

Peptide-ELISA (1)

Host

rabbit (22)

mouse (1)

Isotype

Ig (1)

IgG (5)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (22)

Clone

3B8 (1)

Format

96-Well Strip Plate (1)

APC (2)

APC Conjugated (2)

Biotin Conjugated (2)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (9)

Epitope

aa1246-1346 (8)

aa1335-1435 (8)

N-Terminus (1)

aa1100-1150 (1)

Publications

No (30)

Sample Type

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

His-GST (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Select

NISCH Antibody (clone 3B8) LS-C139385

Antibody:

NISCH Mouse anti-Human Monoclonal (3B8) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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NISCH Antibody LS-C676161

Antibody:

NISCH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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NISCH Antibody LS-C667175

Antibody:

NISCH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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NISCH Antibody (N-Terminus) LS-C757772

Antibody:

NISCH Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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NISCH Antibody LS-C803520

Antibody:

NISCH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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NISCH Antibody (aa1335-1435) LS-C314440

Antibody:

NISCH Rabbit anti-Mouse Polyclonal (aa1335-1435) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161

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NISCH Antibody (aa1335-1435, HRP) LS-C706945

Antibody:

NISCH Rabbit anti-Mouse Polyclonal (aa1335-1435) (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$329; 200 µl/$379; 500 µl/$547; 1 ml/$649; 2 ml/$884; 5 ml/$1,475

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NISCH Antibody (aa1335-1435, Biotin) LS-C684247

Antibody:

NISCH Rabbit anti-Mouse Polyclonal (aa1335-1435) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567; 2 ml/$769; 5 ml/$1,248

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NISCH Antibody (aa1335-1435, FITC) LS-C690456

Antibody:

NISCH Rabbit anti-Mouse Polyclonal (aa1335-1435) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$338; 200 µl/$392; 500 µl/$573; 1 ml/$698; 2 ml/$936; 5 ml/$1,588

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NISCH Antibody (aa1335-1435, PE) LS-C721004

Antibody:

NISCH Rabbit anti-Mouse Polyclonal (aa1335-1435) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269

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NISCH Antibody (aa1335-1435, APC, Cy7) LS-C730013

Antibody:

NISCH Rabbit anti-Mouse Polyclonal (aa1335-1435) (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$483; 200 µl/$599; 500 µl/$1,089; 1 ml/$1,297; 2 ml/$1,815; 5 ml/$3,403

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NISCH Antibody (aa1335-1435, APC) LS-C715353

Antibody:

NISCH Rabbit anti-Mouse Polyclonal (aa1335-1435) (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269

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NISCH Antibody (aa1335-1435, Cy3) LS-C697921

Antibody:

NISCH Rabbit anti-Mouse Polyclonal (aa1335-1435) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC, Cy7
• APC
• More...
  • Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC, Cy7
  • APC
  • Cy3

Select

NISCH Antibody (aa1246-1346) LS-C314437

Antibody:

NISCH Rabbit anti-Human Polyclonal (aa1246-1346) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141

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NISCH Antibody (aa1246-1346, HRP) LS-C706944

Antibody:

NISCH Rabbit anti-Human Polyclonal (aa1246-1346) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$325; 200 µl/$375; 500 µl/$539; 1 ml/$632; 2 ml/$867; 5 ml/$1,439

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NISCH Antibody (aa1246-1346, Biotin) LS-C684246

Antibody:

NISCH Rabbit anti-Human Polyclonal (aa1246-1346) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217

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NISCH Antibody (aa1246-1346, FITC) LS-C690457

Antibody:

NISCH Rabbit anti-Human Polyclonal (aa1246-1346) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$334; 200 µl/$387; 500 µl/$565; 1 ml/$682; 2 ml/$919; 5 ml/$1,549

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NISCH Antibody (aa1246-1346, PE) LS-C721005

Antibody:

NISCH Rabbit anti-Human Polyclonal (aa1246-1346) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213

Select

NISCH Antibody (aa1246-1346, APC, Cy7) LS-C730010

Antibody:

NISCH Rabbit anti-Human Polyclonal (aa1246-1346) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$476; 200 µl/$590; 500 µl/$1,069; 1 ml/$1,265; 2 ml/$1,771; 5 ml/$3,319

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NISCH Antibody (aa1246-1346, APC) LS-C715352

Antibody:

NISCH Rabbit anti-Human Polyclonal (aa1246-1346) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213

Select

NISCH Antibody (aa1246-1346, Cy3) LS-C697922

Antibody:

NISCH Rabbit anti-Human Polyclonal (aa1246-1346) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC, Cy7
• APC
• More...
  • Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC, Cy7
  • APC
  • Cy3

Select

NISCH Antibody LS-C410468

Antibody:

NISCH Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

NISCH Antibody (aa1100-1150) LS-C762962

Antibody:

NISCH Rabbit anti-Human Polyclonal (aa1100-1150) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

NISCH Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114799

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

166.5 kDa

Price:

100 µg/$494

Select

Human NISCH Protein (Recombinant GST, N-terminus) (aa1246-1345) - LS-G61777

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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