Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone MRQ-21] (IgG1) to Human NGFR / CD271 / TNR16
IHC - Paraffin, IHC - Frozen
Mouse Monoclonal (IgG1) to Rat NGFR / CD271 / TNR16
IHC - Frozen, Western blot, Immunoprecipitation, Functional Assay
Rat NGFR / CD271 / TNR16
Rat (tested or 100% immunogen sequence identity)
Ion exchange chromatography
IHC - Frozen
Western blot (1 - 5 µg/ml)
Immunoprecipitation (5 µg/ml)
Specificity and Use
Rat p75, low affinity NGF receptor.
Specific for the rat low affinity Nerve Growth Factor-Receptor (p75).
Suitable for use in Immunohistochemistry (frozen), Immunoprecipitation, Western Blot and Inhibition of NGF binding. Immunohistochemistry (frozen): 1-5 ug/ml on rat. Western Blot: 1-5 ug/ml (Non-reducing conditions only). Immunoprecipitation: 5 ug/ml, 0.5% Triton X-100 buffer, PC12 positive control.
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.