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May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication.
Gene Name: | interleukin enhancer binding factor 3, 90kDa |
Synonyms: | ILF3, CBTF, DRBF, DRBP76, MMP4, NF-AT-90, NF90, NFAR2, Nuclear factor nf90, M-phase phosphoprotein 4, TCP110, MPHOSPH4, NF110b, NF90a, NF90b, NFAR-1, TCP80, NF110, NFAR |
Target Sequences: | NM_004516 NP_004507.2 Q12906 |
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