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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene Name: | neurofilament, medium polypeptide |
Synonyms: | NEFM, 160 kDa neurofilament protein, NEF3, NF-M, NFM, Neurofilament 3 |
Target Sequences: | NM_005382 NP_005373.2 P07197 |
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