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Anti-NCR1 / NKP46 Antibody (clone AKS1) LS-C187493

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $305
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular NCR1 / NKP46 Antibodies

Anti-NCR1 / NKP46 Antibody (Low Endotoxin) LS-C44750
Mouse Monoclonal (IgG1) to Bovine NCR1 / NKP46
Bovine
Western blot, Flow Cytometry, Functional Assay
Unconjugated, Low Endotoxin
Anti-NCR1 / NKP46 Antibody (aa55-104) IHC-plus™ LS-B12032
Rabbit Polyclonal to Human NCR1 / NKP46
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone AKS1] (IgG1) to Bovine NCR1 / NKP46
Bovine
Immunofluorescence, Western blot, Flow Cytometry
Unconjugated

Details

Bovine NCR1 / NKP46
Mouse
Bovine (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [AKS1]
Unconjugated
Protein G purified
Unmodified

Applications

  • Immunofluorescence
  • Western blot
  • Flow Cytometry

Specificity and Use

NCR1 / NKP46 antibody was raised against fusion protein consisting of the extracellular region of bovine CD335.
Clone AKS1 is specific for bovine CD335, also known as NKp46 and Natural cytotoxicity triggering receptor 1. CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor. CD335 is expressed by human natural killer cells. The bovine homologue is expressed on bovine NK cells and no expression of CD335 has been detected on B cells, T cells, monocytes or granulocytes. Clone AKS1 is reported to activate lysis of FcgammaR-expressing cell line P815, by IL-2 activated NKp46+ cells.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About NCR1 / NKP46

O76036 NM_004829 NP_004820.2

NCR1 Antibody, CD335 Antibody, HNKp46 Antibody, NK-p46 Antibody, Lymphocyte antigen 94 homolog Antibody, NK cell-activating receptor Antibody, CD335 antigen Antibody, LY94 Antibody, NKP46 Antibody

NKp46/CD335 is expressed on activated and resting NK cells but not on T or B cells and belongs to a family of receptors termed natural cytotoxicity receptors (NCR). Their engagement induces a strong activation of NK-mediated cytolysis and direct correlation exists between the surface density of NCR and the ability of NK cells to kill various target cells.

Flow Cytometry

Flow Cytometry
Flow cytometry of bovine peripheral blood lymphocytes with Mouse anti-Bovine CD335 followed by Goat anti-Mouse IgG (H/L):FITC . A small positive peak representing NK cells can be identified
 

Requested From: United States
Date Requested: 12/6/2016

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