Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone IC4] (IgG1) to Mouse NC1.1
Western blot, Immunoprecipitation, Flow Cytometry, Functional Assay
Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [IC4]
Flow Cytometry (1:20 - 1:40)
Specificity and Use
NC1.1 antibody was raised against spleen cells from CBA mice.
Recognizes an alloantigen designated NC1.1 expressed by murine natural cytotoxic cells. (NC1.1 is a 45kD cell surface antigen). Natural cytotoxic cells represent a small subset of cells with cytotoxic activity against certain tumor cells in functional assays. Has been shown to block substantially NC cells activity in vivo and in vitro. Recognizes the NC1.1 alloantigen in CBA, C57BL/6, BALB/c and NZB mice, but not in CE or DBA/2 mice.