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Anti-NBN / Nibrin Antibody LS-C43025

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $540
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Most Popular NBN / Nibrin Antibodies

Anti-NBN / Nibrin Antibody (clone 1D7) IHC-plus™ LS-B1701
Mouse Monoclonal [clone 1D7] (IgG1) to Human NBN / Nibrin
Human
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image
Anti-NBN / Nibrin Antibody (N-Terminus) LS-C153699
Rabbit Polyclonal to Human NBN / Nibrin
Human
IHC, Western blot
Unconjugated
Immunohistochemistry Image
Anti-NBN / Nibrin Antibody (aa609-638, APC) LS-C223408
Rabbit Polyclonal (IgG) to Human NBN / Nibrin
Human
ICC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
APC Conjugated

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human NBN / Nibrin
Human
Western blot, Immunoprecipitation
Unconjugated

Details

Human NBN / Nibrin
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Purified
Unmodified

Applications

  • Western blot (1:1000 - 1:10000)
  • Immunoprecipitation

Specificity and Use

NBN / Nibrin antibody was raised against synthetic peptide corresponding to a region within human NBS1 (locus link ID 4683).
Recognizes human Nijmegen breakage syndrome 1, also known as nibrin, NBS1 or Cell cycle regulatory protein p95. NBS1 interacts with MRE11 and RAD50 to form a complex with nuclease activity which is involved in the initiation of nonhomologous end joining and homologous recombination. It is thought that NBS1 is involved in both DNA double-strand break repair and DNA damage-induced checkpoint activation. Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by hypersensitivity to ionizing radiation and cancer predisposition.

Packaging

Tris-citrate/phosphate, pH 7.5, 0.09% sodium azide.
For research use only.

About NBN / Nibrin

O60934 NM_002485 NP_002476.2

NBN Antibody, ATV Antibody, AT-V2 Antibody, Nibrin Antibody, NBS1 Antibody, AT-V1 Antibody, NBS Antibody, p95 Antibody

Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A.

Western blot

Western blot
Detection of human NBS1 in nuclear extracts from HeLa cells and 293T cells by Western blotting and from HeLa cells by immunoprecipitation with Rabbit anti-Human NBS1 (LS-C43025) NBS1 was also immunoprecipitated with an antibody directed to an alternate region of the molecule.
 

Requested From: United States
Date Requested: 12/3/2016

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