Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC, IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation
Rabbit Polyclonal to Human NALP1 / NLRP1
Human NALP1 / NLRP1
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
Specificity and Use
NALP1 / NLRP1 antibody was raised against synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) of N-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein). Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (96%); Marmoset (88%).
Recognizes human NALP1.
0.02% sodium azide.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
NALP1 / NLRP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells.