Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse (tested or 100% immunogen sequence identity)
Tissue culture supernatant
IHC - Paraffin (1:20)
Specificity and Use
Murine macrophage precursor cells
Nature and function of the surface localized antigen are unknown. The antigen failed to immunoprecipitate. Antigen distribution: Isolated cells: The antigen is present on bone marrow myeloid cells (over 60 % of freshly isolated bone marrow cells) including all M-CSF responsive cells. On myeloid cell lines the antigen is highly expressed in cells showing characteristics of cell precursors. Expression of the antigen decreases with maturation of macrophages. Tissue sections: The antigen can be detected in all tissues containing myelopoietic islands. Specificity: Mouse: Myelopoietic cells, all macrophage precursor cells Other species: unknown