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MYCBP binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene.
Gene Name: | MYC binding protein |
Synonyms: | MYCBP, AMY-1, Associate of Myc 1, C-Myc-binding protein, Associate of myc-1, C-myc binding protein, AMY1 |
Target Sequences: | NM_012333 NP_036465.2 Q99417 |
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