Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
MTMR4 Antibody, FYVE-DSP2 Antibody, KIAA0647 Antibody, Myotubularin-related protein 4 Antibody, Myotubularin related protein 4 Antibody, ZFYVE11 Antibody
Myotubularin-related protein 4 (MTMR4), a myotubularin-related phosphatase, has been shown to contain the consensus active site of dual specificity protein phosphatases (DSPs) and to share inhibition and inactivation characteristics with other DSPs. Similar to other myotubularin-related proteins, MTMR4 has been shown to possess a SET (Suvar3-9, Enhancer of zeste, trithorax)-interacting domain (SID) which may mediate interactions with SET domains present in chromatin-organizing nuclear proteins.
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with MTMR4 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
The anti-MTMR4 antibody is used in Western blot to detect MTMR4 in mouse heart cell lysate.