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MTF-1 is a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).
Gene Name: | metal-regulatory transcription factor 1 |
Synonyms: | MTF1, MTF-1, Transcription factor MTF-1, Zinc regulatory factor, ZRF |
Target Sequences: | NM_005955 NP_005946.2 Q14872 |
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