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Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Gene Name: | methylthioadenosine phosphorylase |
Synonyms: | MTAP, BDMF, C86fus, DMSFH, MSAP, MTA phosphorylase, LGMBF, MeSAdo phosphorylase, MTAPase, DMSMFH |
Target Sequences: | NM_002451 NP_002442.2 Q13126 |
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