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Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
Gene Name: | msh homeobox 2 |
Synonyms: | MSX2, CRS2, HOX8, Homeobox protein Hox-8, Homeobox protein MSX-2, Msh homeo box 2, Parietal foramina 1, PFM1, MSH, Msh homeobox 2, Msh homeobox homolog 2, PFM, FPP |
Target Sequences: | NM_002449 NP_002440.2 P35548 |
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