Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone RBT-MSH2] (IgG) to Human MSH2
IHC, IHC - Paraffin, IHC - Frozen
Mouse Monoclonal (IgG1,k) to Human MSH2
IHC, IHC - Paraffin
Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
IHC - Paraffin
Specificity and Use
MSH2 antibody was raised against recombinant human MSH2 protein. Cellular Localization: Nuclear.
Recognizes human MSH2.
Suitable for use in Immunohistochemistry. Immunohistochemistry: (formalin/paraffin): 1:5 for 60 min at RT) requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Positive control: Tonsil.
0.09% sodium azide.
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.