Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat, Human, Mouse, Horse, Rabbit (tested or 100% immunogen sequence identity)
IHC - Paraffin (5 µg/ml)
Western blot (0.5 - 4 µg/ml)
Specificity and Use
MMP3 antibody was raised against synthetic peptide surrounding amino acid 465 of rat MMP-3.
The antibody recognizes the MMP-3 of human, mouse, rat, horse, and rabbit origins. Reactivity to other species has not been tested. The antibody detects the 55 kD full length and the 21 kD cleavage fragment of MMP-3.
PBS, 30% glycerol, 0.5% BSA, 0.01% Thimerosal.
+4°C or -20°C, Avoid repeated freezing and thawing.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.