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Anti-MMP1 Antibody (C-Terminus, clone 3B6) LS-C188387

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $330
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular MMP1 Antibodies

Anti-MMP1 Antibody (N-Terminus) IHC-plus™ LS-B1229
Rabbit Polyclonal to Human MMP1
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-MMP1 Antibody (C-Terminus) IHC-plus™ LS-B5276
Rabbit Polyclonal (IgG) to Human MMP1
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-MMP1 Antibody LS-C150002
Goat Polyclonal (IgG) to Human MMP1
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 3B6] (IgG1) to Human MMP1
Human
IHC - Paraffin, Western blot
Unconjugated

Details

Human MMP1
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [3B6]
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin
  • Western blot

Specificity and Use

MMP1 antibody was raised against ovalbumin conjugated synthetic peptide corresponding to a region within the C-terminus of human MMP-1.
C-Terminus
Recognizes human matrix metalloproteinase 1 (MMP-1). The MMPs are zinc-dependent endopeptidases responsible for degrading the extracellular matrix. They are also involved in cell proliferation, migration, differentiation and apoptosis. Most MMPs are synthesized as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis. MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma. It is overexpressed in invasive melanoma, colorectal and esophageal cancers. It has also been implicated in arthritis and might influence atherosclerotic lesion formation. It might also be involved in the repair processes of the heart after myocardial infarction.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About MMP1

P03956 NM_002421 NP_002412.1

MMP1 Antibody, CLG Antibody, Fibroblast collagenase Antibody, Matrix metalloprotease 1 Antibody, MMP-1 Antibody, Interstitial collagenase Antibody, Matrix metalloproteinase 1 Antibody, Matrix metalloproteinase-1 Antibody

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III.

Immunohistochemistry

Immunohistochemistry
Immunohistochemistry of paraffin-embedded normal human colon with Mouse anti-Human MMP-1 after citrate retrieval
 

Requested From: United States
Date Requested: 12/10/2016

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