Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal [clone E19-P] to Human MME / CD10
IHC, IHC - Paraffin
Mouse Monoclonal [clone 56C6] (IgG1) to Human MME / CD10
IHC, IHC - Paraffin, IHC - Frozen, Western blot
Human MME / CD10
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [56C6]
Tissue culture supernatant
IHC - Paraffin (1:80)
IHC - Frozen (1:80)
Western blot (1:50 - 1:100)
Specificity and Use
MME / CD10 antibody was raised against recombinant human CD10.
Recognizes the human CD10 cell surface antigen, a ~100 kD glycoprotein also known as CALLA (common acute lymphoblastic leukaemia antigen). CD10 is expressed on a variety of cell types, including immature and germinal centre B cells, lymphoblastic leukaemia cells and also on the brush border of kidney epithelial cells.
Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.
MME / CD10 is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues.